Brain death results in the inability to secrete which hormone that affects blood pressure regulation?

Brain death leads to the loss of all brain functions, including those related to the hypothalamus and pituitary gland, which are crucial for the secretion of various hormones that help regulate bodily functions, including blood pressure. In this context, adrenocorticotropic hormone (ACTH) plays a significant role. ACTH is produced in the anterior pituitary gland and stimulates the adrenal glands to produce cortisol, a hormone involved in stress responses and maintaining cardiovascular stability.

When brain death occurs, the body can no longer produce ACTH due to the loss of signaling from the brain. This decrease in ACTH means that the adrenal glands will not receive the necessary stimulation to produce cortisol, leading to potential life-threatening conditions such as adrenal crisis, which can severely affect blood pressure and other metabolic processes.

The other hormone choices impact bodily functions but do not have a direct relation to brain death in terms of immediate loss of secretion that critically affects blood pressure regulation like ACTH does. Insulin is primarily associated with glucose metabolism, antidiuretic hormone (ADH) regulates water balance, and cortisol also relates to stress response but depends on ACTH for its stimulation. Hence, the most relevant hormone that cannot be secreted due to brain death in the context of blood