Certified Clinical Transplant Nurse (CCTN) Practice Exam

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What is the half-life of DDAVP in a donor with healthy kidneys?

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The half-life of DDAVP (desmopressin) in a donor with healthy kidneys typically ranges around 3 hours. This duration is significant because it indicates how long the drug remains active in the body after administration.

Understanding the half-life is crucial for managing the dosing and timing of DDAVP, especially in a clinical transplant setting where effective hemostasis is necessary. Given that DDAVP is used primarily to increase levels of factor VIII, its pharmacokinetic properties, including the half-life, impact the management of patients undergoing procedures such as donations or transplants. A shorter half-life may necessitate more frequent dosing or monitoring, while a longer half-life could allow for less frequent administration.

This information is vital for clinicians to ensure optimal therapeutic effects while minimizing potential side effects.

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